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Relizen Hot Flash & Night Sweat Relief Tablets by Bonafide

A focused daily supplement for hot flashes and night sweats, built around purified Swedish flower pollen extract in a simple two-tablet routine.

GenMeno Editorial·Reviewed June 2026·6 min read
87
out of 100
GenMeno Score
GenMeno Favorite

Relizen Hot Flash & Night Sweat Relief Tablets earns a GenMeno score of 87 because its standardized PI-82 and GC-FEM pollen extract blend has direct placebo-controlled support for hot flashes, and the 320 mg daily total matches the dose used in published studies. This is a strong, focused option for women whose main concerns are hot flashes and night sweats, although the current label does not disclose the amount of each extract.

Placebo-controlled supportStudy-matched 320 mg total doseDirect hot flash benefitFocused two-tablet routineIndividual extract doses not disclosed
85–100 = GenMeno Favorite. See all score tiers →
At a glance
  • Package60 tablets
  • Serving2 tablets daily
  • SupplyAbout 30 days
  • Typical Price$58 one-time; plans from $38/month
  • Available FromAmazon and Bonafide
Good choice if:
  • You want focused support for hot flashes and night sweats
  • You want a formula built around one studied pollen extract blend
  • You are comfortable using it consistently before judging results
Look elsewhere if:
  • You want the exact amount of every active extract disclosed
  • You need fast or as-needed relief
  • Your main priorities fall outside hot flashes and night sweats
See the full breakdown
Why It Earned This Rating
Highlights
  • 320 mg daily total matches the dose used in published studies
  • A randomized, double-blind trial found greater hot flash improvement than placebo
  • Additional human studies support the ingredient's hot flash focus
  • Simple two-tablet once-daily routine
Trade-Offs
  • Relizen does not disclose the individual PI-82 and GC-FEM amounts
Relizen previous packaging
See the package
Relizen ingredients and Supplement Facts from previous packaging
Check the ingredients

This review may contain affiliate links. If you purchase through them, GenMeno may earn a commission at no extra cost to you. We review products using publicly available labels, retailer information, brand materials, and, when needed, purchased samples or brand-provided samples. Our scores and conclusions are independent of how we received them. How GenMeno reviews products →


Relizen for Hot Flashes and Menopause Symptoms

The ingredient evidence is most relevant to hot flashes and night sweats. It may also be relevant when night sweats are disrupting sleep.

Most relevant for
  • Hot flashes
  • Night sweats
Less directly supported for
  • Brain fog or mood
  • Weight changes or joint pain
  • Vaginal dryness or libido
  • Skin or hair changes
Not sure which menopause symptoms are yours? The GenMeno Pattern Tracker helps you find the pattern underneath the noise.Find my symptom patterns →

What you need to know before buying

Relizen Ingredients and Clinical Evidence A randomized, double-blind, placebo-controlled trial enrolled 64 menopausal women, with 54 completing three months of treatment. 65% of women taking the pollen extract were classified as hot flash responders, compared with 38% taking placebo. Daily diaries also showed a 27% reduction in hot flashes versus placebo after three months.
What the proprietary blend means for dose verification

The studies behind this ingredient used a standardized blend of PI-82 and GC-FEM at 320 mg daily. PI-82 makes up 75% of that formula, GC-FEM the remaining 25%. Relizen matches the total dose, but the label doesn't break out how much of each extract it contains.

What the broader Sérélys research addsThe evidence extends beyond the original placebo-controlled trial. An 84-day study of 417 women reported improvement in hot flashes and sweats, while a separate 12-week, multicenter observational study followed 104 women taking the same PI-82 and GC-FEM combination and reported a 48.5% reduction in hot flashes. Together, these studies show that the ingredient has been evaluated in several human populations, with the placebo-controlled trial providing the clearest evidence for direct hot flash benefit.
The extract is processed differently from whole pollenPI-82 and GC-FEM are purified cytoplasmic extracts, and the manufacturing process filters out the outer pollen shell where allergenic material is concentrated. Anyone with a known pollen allergy or a history of serious allergic reactions should still check with a healthcare professional before use.
What interaction research has examinedLaboratory and clinical findings have not shown estrogenic activity from the PI-82 and GC-FEM extracts. A separate in-vitro study found negligible inhibition of CYP2D6, an enzyme involved in processing several medications. People receiving cancer treatment should still discuss supplements with their care team.
Allow time to judge the routineThe controlled study evaluated results over three months. Relizen is designed for consistent daily use, not immediate or as-needed relief.
Packaging is being updatedThe product shown here is the previous packaging received from Amazon. It does not show allergen or free-from disclosures, so the Label Disclosure Snapshot below remains NS unless the physical label states otherwise.
Brand-site savings and purchase options
  • A one-time 60-tablet box is $58. The monthly plan is $42 per month, a 27% discount, while the three-month plan is $38 per month, a 34% discount.
  • Qualified shoppers can use pre-tax HSA/FSA funds through Bonafide's Truemed partnership after completing its eligibility process.
  • Returns are limited to unopened, unused products. First-time orders have a 30-day return window; recurring orders have a 14-day window. Bonafide deducts a $7 return shipping fee from refunds.
Label Disclosure Snapshot Based on the product label available at time of review. This snapshot reflects which common allergen and attribute disclosures are clearly shown on the product label reviewed.
Soy freeNS
Milk / Dairy freeNS
Egg freeNS
Fish freeNS
Shellfish freeNS
Tree nut freeNS
Peanut freeNS
Wheat / Gluten freeNS
Sesame freeNS
GMO freeNS
Shown on labelNS Not shown on label
Brand Site Disclosure Snapshot Based on the brand's official product page at time of review, verified June 2026.
Soy free
Milk / Dairy freeNS
Egg freeNS
Fish freeNS
Shellfish freeNS
Tree nut freeNS
Peanut freeNS
Wheat / Gluten free
Sesame freeNS
GMO free
Shown on brand siteNS Not shown on brand site
Relizen Cost and Buying Guidance

If hot flashes and night sweats are the symptoms you most want to address, and you prefer a focused formula over a broad multi-symptom blend, Relizen is a strong fit to consider. Its 320 mg daily pollen extract total matches the dose used in published studies, and Bonafide's subscription options make the ongoing routine less expensive than buying one box at a time.

Relizen Hot Flash and Night Sweat Relief bottle
Relizen Hot Flash & Night Sweat Relief Tablets
Official Bonafide prices: $58 one-time · $42/month monthly plan · $38/month three-month plan
About this review

How GenMeno evaluates supplements

Every product goes through the same independent scoring process before we publish. We evaluate across four dimensions: evidence and formulation, safety and transparency, user experience, and market validation.

Affiliate links, brand samples, and commercial relationships do not determine how a product is evaluated. Every score reflects the product, not the relationship.

Evidence & formulationSafety & transparencyUser experienceMarket validation
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